Publications

2016

Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structure and mechanism of human PrimPol, a DNA polymerase with primase activity. Science Advances 2016 Oct 21;2:e160131.

Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Structures of NS5 Methyltransferase from Zika Virus. Cell Rep. 2016 Sep 20;16(12):3097-102.

Jain R, Coloma J, García-Sastre A, Aggarwal AK. Structure of the NS3 helicase from Zika virus. Nat Struct Mol Biol. 2016 Aug;23(8):752-4.

Athuluri-Divakar SK, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP. A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell. 2016 Apr 21;165(3):643-55.

Callahan SJ, Luyten YA, Gupta YK, Wilson GG, Roberts RJ, Morgan RD, Aggarwal AK. Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biol. 2016 Apr 15;14(4):e1002442.

Coloma J, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase α in binary complex with a DNA:DNA template-primer. Sci Rep. 2016 Apr 1;6:23784

Reddy MV, Akula B, Jatiani S, Vasquez-Del Carpio R, Billa VK, Mallireddigari MR, Cosenza SC, Venkata Subbaiah DR, Bharathi EV, Pallela VR, Ramkumar P, Jain R, Aggarwal AK, Reddy EP. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimi din-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44.

2015

Gupta YK, Chan SH, Xu SY, Aggarwal AK. Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nature Communications 2015 Jun 12;6:7363.

Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S. An Inhibitor of PIDDosome Formation. Mol Cell. 2015 Jun 4;58(5):767-79.

Chen X, Khajeh JA, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJ, Bu Z. Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering. J Biol Chem. 2015 Mar 6;290(10):6639-52.

Puc J, Kozbial P, Li W, Tan Y, Liu Z, Suter T, Ohgi KA, Zhang J, Aggarwal AK, Rosenfeld MG. Ligand-dependent enhancer activation regulated by topoisomerase-I activity. Cell. 2015 Jan 29;160(3):367-80.

2014

Yuen T, Stachnik A, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Bailey J, Latif Y, Mujtaba S, Epstein S, Davies TF, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Bisphosphonates inactivate human EGFRs to exert antitumor actions. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17989-94.

Stachnik A, Yuen T, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Scherer T, Mujtaba S, Galsky M, Gomez J, Epstein S, Buettner C, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17995-8000.

Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Crystal structure of yeast DNA polymerase ε catalytic domain. PLoS One. 2014 Apr 14;9(4):e94835.

Jain R, Vanamee ES, Dzikovski BG, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε. J Mol Biol. 2014 Jan 23;426(2):301-8.

2013

Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, Aggarwal AK, Rosenfeld MG. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell. 2013 Dec 19;155(7):1581-95.

Gómez-Llorente Y, Malik R, Jain R, Choudhury JR, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. The architecture of yeast DNA polymerase ζ. Cell Rep. 2013 Oct 17;5(1):79-86.

2012

De Ioannes P, Malu S, Cortes P, Aggarwal AK. Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Rep. 2012 Dec 27;2(6):1505-12.

Ferrage F, Dutta K, Nistal-Villán E, Patel JR, Sánchez-Aparicio MT, De Ioannes P, Buku A, Aseguinolaza GG, García-Sastre A, Aggarwal AK. Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation. Structure. 2012 Dec 5;20(12):2048-61

Ummat A, Rechkoblit O, Jain R, Roy Choudhury J, Johnson RE, Silverstein TD, Buku A, Lone S, Prakash L, Prakash S, Aggarwal AK. Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nat Struct Mol Biol. 2012 May 6;19(6):628-32.

Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK. Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering. J Mol Biol. 2012 Jul 20;420(4-5):261-8.

Xu S.Y., Nugent R.L., Kasamkattil J., Fomenkov A., Gupta Y., Aggarwal A., Wang X., Li Z., Zheng Y., Morgan R. Characterization of Type II and III restriction-modification systems from Bacillus cereus strains ATCC10987 and ATCC14579. J Bacteriol. 2012 Jan;194(1):49-60.

Reddy EP, Aggarwal AK. The ins and outs of bcr-abl inhibition. Genes Cancer. 2012 May;3(5-6):447-54.

Malu S, De Ioannes P, Kozlov M, Greene M, Francis D, Hanna M, Pena J, Escalante CR, Kurosawa A, Erdjument-Bromage H, Tempst P, Adachi N, Vezzoni P, Villa A, Aggarwal AK, Cortes P . Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med. 2012 May 7;209(5):955-63.

Ummat A, Silverstein TD, Jain R, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase η is pre-aligned for dNTP binding and catalysis. J Mol Biol. 2012 Jan 27;415(4):627-34.

2011

Callahan SJ, Morgan RD, Jain R, Townson SA, Wilson GG, Roberts RJ, Aggarwal AK. Crystallization and preliminary crystallographic analysis of the type IIL restriction enzyme MmeI in complex with DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1262-5.

De Ioannes P, Escalante CR, Aggarwal AK. Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Res. 2011 Sep 1;39(16):7300-7. doi: 10.1093/nar/gkr325. Epub 2011 May 19.

Vasquez-Del Carpio R, Silverstein TD, Lone S, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Role of human DNA polymerase Κ in extension opposite from a cis-syn thymine dimer. J Mol Biol. 2011 Apr 29;408(2):252-61.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase. J Mol Biol. 2011 Feb 11;406(1):18-28.

Silverstein TD, Jain R, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η. Structure. 2010 Nov 10;18(11):1463-70.

Vanamee ES, Viadiu H, Chan SH, Ummat A, Hartline AM, Xu SY, Aggarwal AK. Asymmetric DNA recognition by the OkrAI endonuclease, an isoschizomer of BamHI. Nucleic Acids Res. 2011 Jan;39(2):712-9.

2010

Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.Nature. 2010 Jul 22;466(7305):508-12.

Silverstein TD, Johnson RE, Jain R, Prakash L, Prakash S, Aggarwal AK. Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature. 2010 Jun 24;465(7301):1039-43.

Nistal-Villan E, Gack MU, Martinez-Delgado G, Maharaj NP, Inn KS, Yang H, Wang R, Aggarwal AK, Jung JU, Garcia-Sastre A. Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production. J Biol Chem.
2010 Jun 25;285(26):20252-61.

2009

Jain R, Hammel M, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural insights into yeast DNA polymerase delta by small angle X-ray scattering. J Mol Biol. 2009 Dec 4;394(3):377-82.

Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta. Nat Struct Mol Biol. 2009 Sep;16(9):979-86.

Jain R, Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Replication across template T/U by human DNA polymerase-iota. Structure. 2009 Jul
15;17(7):974-80.

Vasquez-Del Carpio R, Silverstein TD, Lone S, Swan MK, Choudhury JR, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. PLoS One. 2009 Jun 2;4(6):e5766.

Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structure of the human Rev1-DNA-dNTP ternary complex. J Mol Biol. 2009 Jul 24;390(4):699-709.

Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK. Co-occupancy of two Pumilio molecules on a single hunchback NRE. RNA. 2009 Jun;15(6):1029-35.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. DNA synthesis across an abasic lesion by human DNA polymerase iota. Structure. 2009 Apr 15;17(4):530-7.

2008

Gupta YK, Nair DT, Wharton RP, Aggarwal AK. Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure. 2008 Apr;16(4):549-57.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Protein template directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Structure. 2008 Feb;16(2):239-45.

2007

Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007 Nov 2;131(3):530-43.

Escalante CR, Nistal-Villan E, Shen L, Garcia-Sastre A, Aggarwal AK. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol Cell. 2007 Jun 8;26(5):703-16.

Vanamee ES, Berriman J, Aggarwal AK. An EM view of the FokI synaptic complex by single particle analysis. J Mol Biol. 2007 Jul 6;370(2):207-12.

Townson SA, Samuelson JC, Bao Y, Xu SY, Aggarwal AK. BstYI bound to noncognate DNA reveals a “hemispecific” complex: implications for DNA

Niv MY, Ripoll DR, Vila JA, Liwo A, Vanamee ES, Aggarwal AK, Weinstein H, Scheraga HA. Topology of Type II REases revisited; structural classes and the common conserved core. Nucleic Acids Res. 2007;35(7):2227-37.canning. Structure. 2007 Apr;15(4):449-59.

Lone S, Townson SA, Uljon SN, Johnson RE, Brahma A, Nair DT, Prakash S, Prakash L, Aggarwal AK. Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell. 2007 Feb 23;25(4):601-14.

2006

Wharton RP, Aggarwal AK. mRNA regulation by Puf domain proteins. Sci STKE. 2006 Sep 26;2006(354):pe37.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat Struct Mol Biol. 2006 Jul;13(7):619-25.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Structure. 2006 Apr;14(4):749-55.

Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG 3rd, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol. 2006 Mar 10;356(5):1065-72.

2005

Vanamee ES, Viadiu H, Kucera R, Dorner L, Picone S, Schildkraut I, Aggarwal AK. A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA. EMBO J. 2005 Dec 7;24(23):4198-208. Epub 2005 Nov 24.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Structure. 2005 Oct;13(10):1569-77.

Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ. Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15053-8.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science. 2005 Sep 30;309(5744):2219-22.

Townson SA, Samuelson JC, Xu SY, Aggarwal AK. Implications for switching restriction enzyme specificities from the structure of BstYI bound to a BglII DNA sequence. Structure. 2005 May;13(5):791-801.

2004

Yoon-Robarts M, Blouin AG, Bleker S, Kleinschmidt JA, Aggarwal AK, Escalante CR, Linden RM. Residues within the B’ motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2. J Biol Chem. 2004 Nov 26;279(48):50472-81.

James JA, Aggarwal AK, Linden RM, Escalante CR. Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12455-60.

Uljon SN, Johnson RE, Edwards TA, Prakash S, Prakash L, Aggarwal AK. Crystal structure of the catalytic core of human DNA polymerase kappa. Structure. 2004 Aug;12(8):1395-404.

Nair DT, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature. 2004 Jul 15;430(6997):377-80.

Townson SA, Samuelson JC, Vanamee ES, Edwards TA, Escalante CR, Xu SY, Aggarwal AK. Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII. J Mol Biol. 2004 May 7;338(4):725-33.

Trincao J, Johnson RE, Wolfle WT, Escalante CR, Prakash S, Prakash L, Aggarwal AK. Dpo4 is hindered in extending a G.T mismatch by a reverse wobble. Nat Struct Mol Biol. 2004 May;11(5):457-62. Epub 2004 Apr 11.

2003

Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54.

Vanamee ES, Hsieh Pc, Zhu Z, Yates D, Garman E, Xu Sy, Aggarwal AK. Glucocorticoid receptor-like Zn(Cys)4 motifs in BslI restriction endonuclease. J Mol Biol. 2003 Nov 28;334(3):595-603.

Edwards TA, Wilkinson BD, Wharton RP, Aggarwal AK. Model of the brain tumor-Pumilio translation repressor complex. Genes Dev. 2003 Oct 15;17(20):2508-13.

James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK. Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure. 2003 Aug;11(8):1025-35

Viadiu H, Vanamee ES, Jacobson EM, Schildkraut I, Aggarwal AK. Crystallization of restriction endonuclease SfiI in complex with DNA. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1493-5.

Green JB, Gardner CD, Wharton RP, Aggarwal AK. RNA recognition via the SAM domain of Smaug. Mol Cell. 2003 Jun;11(6):1537-48.

Sun J, Viadiu H, Aggarwal AK, Weinstein H. Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex. Biophys J. 2003 May;84(5):3317-25.

Johnson RE, Trincao J, Aggarwal AK, Prakash S, Prakash L. Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases. Mol Cell Biol. 2003 Apr;23(8):3008-12.

2002

Escalante CR, Brass AL, Pongubala JM, Shatova E, Shen L, Singh H, Aggarwal AK. Crystal structure of PU.1/IRF-4/DNA ternary complex. Mol Cell. 2002 Nov;10(5):1097-105.

Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK. Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol Cell. 2002 Oct;10(4):857-69.

Dean KA, Aggarwal AK, Wharton RP. Translational repressors in Drosophila. Trends Genet. 2002 Nov;18(11):572-7.

Green JB, Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK. Crystallization and characterization of Smaug: a novel RNA-binding motif. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1085-8.

Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK. Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. J Struct Biol. 2002 Jul;139(1):55-9.

Escalante CR, Shen L, Thanos D, Aggarwal AK. Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter. Structure. 2002 Mar;10(3):383-91.

2001

Trincao J, Johnson RE, Escalante CR, Prakash S, Prakash L, Aggarwal AK. Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Mol Cell. 2001 Aug;8(2):417-26.

Yoon M, Smith DH, Ward P, Medrano FJ, Aggarwal AK, Linden RM. Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro. J Virol. 2001 Apr;75(7):3230-9.

Vanamee ES, Santagata S, Aggarwal AK. FokI requires two specific DNA sites for cleavage. J Mol Biol. 2001 May 25;309(1):69-78.

Edwards TA, Pyle SE, Wharton RP, Aggarwal AK. Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell. 2001 Apr 20;105(2):281-9.

Lukacs CM, Aggarwal AK. BglII and MunI: what a difference a base makes. Curr Opin Struct Biol. 2001

Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK. Structure of free BglII reveals an unprecedented scissor-like motion for opening an endonuclease. Nat Struct Biol. 2001 Feb;8(2):126-30.

2000

Edwards TA, Trincao J, Escalante CR, Wharton RP, Aggarwal AK. Crystallization and characterization of Pumilo: a novel RNA binding protein. J Struct Biol. 2000 Dec;132(3):251-4.

Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carrière C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science. 2000 Nov 10;290(5494):1127-31.

Senger K, Merika M, Agalioti T, Yie J, Escalante CR, Chen G, Aggarwal AK, Thanos D. Gene repression by coactivator repulsion. Mol Cell. 2000 Oct;6(4):931-7.

Viadiu H, Aggarwal AK. Structure of BamHI bound to nonspecific DNA: a model for DNA sliding. Mol Cell. 2000 May;5(5):889-95.

Viadiu H, Kucera R, Schildkraut I, Aggarwal AK. Crystallization of restriction endonuclease BamHI with nonspecific DNA. J Struct Biol. 2000 May;130(1):81-5

Qiu L, Escalante CR, Aggarwal AK, Wilson PD, Burrow CR. Monomeric midkine induces tumor cell proliferation in the absence of cell-surface proteoglycan binding. Biochemistry. 2000 May 23;39(20):5977-87.

Lukacs CM, Kucera R, Schildkraut I, Aggarwal AK.Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution.. Nat Struct Biol. 2000 Feb;7(2):134-40.

1999

Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 1999 Jun 3;399(6735):491-6.

Dasen JS, O’Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG. Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell. 1999 May 28;97(5):587-98.

Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. Structure and ligand of a histone acetyltransferase bromodomain. Nature. 1999 Jun 3;399(6735):491-6.

Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature. 1999 Feb 25;397(6721):714-9.

1998

Viadiu H, Aggarwal AK. The role of metals in catalysis by the restriction endonuclease BamHI. Nat Struct Biol. 1998 Oct;5(10):910-6.

Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG. Signal-specific co-activator domain requirements for Pit-1 activation. Nature. 1998 Sep 17;395(6699):301-6.

Bitinaite J, Wah DA, Aggarwal AK, Schildkraut I. FokI dimerization is required for DNA cleavage. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10570-5.

Wah DA, Bitinaite J, Schildkraut I, Aggarwal AK. Structure of FokI has implications for DNA cleavage. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10564-9.

Aggarwal AK, Wah DA. Novel site-specific DNA endonucleases. Curr Opin Struct Biol. 1998 Feb;8(1):19-25.

Escalante CR, Yie J, Thanos D, Aggarwal AK. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature. 1998 Jan 1;391(6662):103-6.

1997

Escalante CR, Yie J, Thanos D, Aggarwal AK. Expression, purification, and
co-crystallization of IRF-I bound to the interferon-beta element PRDI. FEBS Lett. 1997 Sep 8;414(2):219-20.

Wah DA, Hirsch JA, Dorner LF, Schildkraut I, Aggarwal AK. Structure of the
multimodular endonuclease FokI bound to DNA. Nature. 1997 Jul 3;388(6637):97-100.

Aggarwal AK. Homing in on intron-encoded endonucleases. Nat Struct Biol. 1997 Jun;4(6):423-4.

Hirsch JA, Wah DA, Dorner LF, Schildkraut I, Aggarwal AK. Crystallization and preliminary X-ray analysis of restriction endonuclease FokI bound to DNA. FEBS Lett. 1997 Feb 17;403(2):136-8. PubMed PMID: 9042953.

Jacobson EM, Li P, Leon-del-Rio A, Rosenfeld MG, Aggarwal AK. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev. 1997 Jan 15;11(2):198-212.

1996

Jacobson EM, Li P, Rosenfeld MG, Aggarwal AK. Crystallization and preliminary X-ray analysis of Pit-1 POU domain complexed to a 28 base pair DNA element. Proteins. 1996 Feb;24(2):263-5.

1995

Hirsch JA, Aggarwal AK. Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity. EMBO J. 1995 Dec 15;14(24):6280-91.

Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding.Science. 1995 Aug 4;269(5224):656-63.

Hirsch JA, Aggarwal AK. Purification, crystallization, and preliminary X-ray
diffraction analysis of even-skipped homeodomain complexed to DNA. Proteins. 1995 Mar;21(3):268-71.

Aggarwal AK. A gripping end to NF-kappa B. Nat Struct Biol. 1995 Mar;2(3):184-6.

Aggarwal AK. Structure and function of restriction endonucleases. Curr Opin Struct Biol. 1995 Feb;5(1):11-9.

Strzelecka T, Newman M, Dorner LF, Knott R, Schildkraut I, Aggarwal AK. Crystallization and preliminary X-ray analysis of restriction endonuclease BamHI-DNA complex. J Mol Biol. 1994 Jun 10;239(3):430-2.

Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of restriction endonuclease BamHI phased at 1.95 A resolution by MAD analysis. Structure. 1994 May 15;2(5):439-52.

Newman M, Strzelecka T, Dorner LF, Schildkraut I, Aggarwal AK. Structure of restriction endonuclease BamHI and its relationship to EcoRI. Nature. 1994 Apr 14;368(6472):660-4.

1991

Jack WE, Greenough L, Dorner LF, Xu SY, Strzelecka T, Aggarwal AK, Schildkraut I. Overexpression, purification and crystallization of BamHI endonuclease. Nucleic Acids Res. 1991 Apr 25;19(8):1825-9.

1990

Pabo CO, Aggarwal AK, Jordan SR, Beamer LJ, Obeysekare UR, Harrison SC. Conserved residues make similar contacts in two repressor-operator complexes. Science. 1990 Mar 9;247(4947):1210-3.

Harrison SC, Aggarwal AK. DNA recognition by proteins with the helix-turn-helix motif. Annu Rev Biochem. 1990;59:933-69.

1988

Aggarwal AK, Rodgers DW, Drottar M, Ptashne M, Harrison SC. Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science. 1988 Nov 11;242(4880):899-907.

1985

Aggarwal AK, Neidle S. Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure. Nucleic Acids Res. 1985 Aug 12;13(15):5671-84.

Neidle S, Aggarwal AK, Islam SA, Kuroda R, Brown JR. Structural studies on sequence selectivity in drug-nucleic acid interactions. Prog Clin Biol Res. 1985;172B:135-44.